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The primary editorial goal of Theology and Science is to publish critically reviewed articles that promote the creative mutual interaction between the natural sciences and theology. While the journal assumes the integrity of each domain, its primary aim is to explore this interaction in terms of the implications of the natural sciences for constructive research in philosophical and systematic theology, the philosophical and theological elements within and underlying theoretical research in the natural sciences, and the relations and interactions between theological and scientific methodologies.

The secondary editorial goal is to monitor and critically assess debates and controversies arising in the broader field of science and religion. Thus, Theology and Science will investigate, analyze, and report on issues as they arise with the intention of prompting further academic discussion of them.This editorial policy is formulated with the guiding confidence that a serious dialogue between science and theology will lead to a variety of new and progressive research programs, and that these in turn will yield new insights, deeper understanding, and new knowledge at the frontiers of science and religion.